Endocrine Abstracts

Introduction: Primary hyperparathyroidism (PHPT) results in alterations in carbohydrate metabolism, characterized by insulin resistance, hyperinsulinemia, and glucose intolerance.Objective: The aim of our study was to evaluate carbohydrate metabolism status in patients with PHPT.Methods: One hundred and nine patients with PHPT were investigated, healthy controls included 36 individuals matched by sex age and BMI (BMI=27±5 kg/m...

Introduction: Somatotropinomas are typically recognized when GH excessively secretion causes acromegaly. «Silent» somatotroph adenomas (immunohistochemical evidence of GH excess without biochemical or clinical evidence) and «clinically silent» somatotroph adenomas (immunohistochemical and biochemical evidence without clinical evidence) have occasionally been reported. The relative frequency of each presentation is unknown.<p class="abst...

TSH-secreting pituitary adenoma (thyrotropinoma) is a rare (0.5% of all pituitary adenomas) and usually benign pituitary lesion, arising from the monoclonal expansion of neoplastic thyrotrophes. Thyrotropinoma usually presents with symptoms thyrotoxicosis (milder compared to those originating from the primary thyroid disorders) and mass effects of the pituitary tumour.Aim: To describe the clinical course of thyrotropinoma presented with paroxysmal atrial...

Introduction: The silent corticotropinomas (SC) account for 1.1–6% of surgically removed pituitary adenomas and 17–22% of ACTH-immunoreactive tumours. They do not cause prominent clinical features of hypercortisolism, nor biochemically evident, but show positive immunostaining for ACTH similar to functional corticotropinomas, They usually present as non-functioning adenomas (NFPA) with local mass effects and/or visual impairment.Aim: To describ...

Silent corticotropinomas (SCAs) are a subtype of non-functioning pituitary adenomas (NFPAs) demonstrating positive immunoreactivity for ACTH, but without clinical or biochemical features of hypercortisolism. SCAs typically present as macroadenomas with symptoms related to a local mass effect. In some cases SCAs can transform into hormonal active formations with gradually developing symptoms of hypercortisolism.The aim: To describe a patient with NFPA who...

Objective: To assess the sensitivity of granins – chromogranin A (CgA), secretogranin II (SgII), and secretoneurin (Sn) as biochemical and immunohistochemical markers of non-functioning pituitary adenomas (NFPAs):Methods: 50 patients with NFPAs were included in the study. Tissue samples were immunostained for pituitary hormones, Ki-67, αSU, CgA, SgII, and Sn. Furthermore, we have determined the levels of CgA, SgII in the serum and Sn in the pla...